PIEZO1 Affects Cell Growth and Migration via Microfilament-Mediated YAP ...
Environmental mechanical forces, such as cell membrane stress, cell extrusion, and stretch, have been proven to affect cell growth and migration. Piezo1, a mechanosensitive channel protein, responds directly to endogenous or exogenous mechanical stimuli. Here, we explored the Piezo1 distribution and microfilament morphological changes induced by mechanical forces in the tumor and normal cells ...
Analytical Chemistry Current Issue - ACS Publications
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Analytical Chemistry Journal - ACS Publications
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SERS Performance Factor: A Convenient Parameter for the Enhancement ...
Derived from the typically used surface enhancement factor EF in which accurate parameters are hardly achievable and different from concentration-dependent analytical enhancement factor AEF, SPF distinguishes itself with a simpler calculation and thereby offers a convenient and reliable protocol for the evaluation of the performance of ...
Journal of Agricultural and Food Chemistry
New Analytical Methods A Bifunctional “Two-in-One” Array for Simultaneous Diagnosis of Irritable Bowel Syndrome and Identification of Low-FODMAP Diets Shujie Cheng
Analytical Chemistry Vol. 96 No. 52 - ACS Publications
Read research published in the Analytical Chemistry Vol. 96 Issue 52 on ACS Publications, a trusted source for peer-reviewed journals.
Polarity-Targeted Carbon Dots for Mitochondria and Lysosomes Imaging
Normally, electrostatic-dependent mitochondria localization can cause a decrease/loss of mitochondrial membrane potential (MMP), leading to the corresponding abnormal behaviors. So, achieving subcellular organelle localization and imaging with as little interference on their physiological activity is of significance for understanding cell activity. Herein, we discover and demonstrate that ...
Integrative Quantitative Analysis of Platelet Proteome and Site ...
The role of peripheral blood platelets as indicators of cancer progression is increasingly recognized, and the significance of abnormal glycosylation in platelet function and related disorders is gaining attention. However, the potential of platelets as a source of protein site-specific glycosylation for cancer diagnosis remains underexplored. In this study, we proposed a general pipeline that ...
Spike-In Proteome Enhances Data-Independent Acquisition for Thermal ...
Target deconvolution is essential for elucidating the molecular mechanisms, therapeutic efficacy, and off-target toxicity of small-molecule drugs. Thermal proteome profiling (TPP) is a robust and popular method for identifying drug–protein interactions. Nevertheless, classical implementation of TPP using isobaric labeling of peptides is tedious, time-consuming, and costly. This prompts the ...
Block Electrochemiluminescence of Luminol through O-Etherification and ...
Luminol is a well-known electrochemiluminescence (ECL) fluorophore that is applied in various sensing fields as an ECL reporter. Regulating the signal off/on transition of an ECL fluorophore offers great opportunities for sensors’ design; however, such attempts on luminol are extremely scarce as it was regarded to lack promising modification sites. In this study, we developed four luminol ...
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